CBG “cannabigerol”
How CBG Interacts with the Endocannabinoid System
CBG interacts with the body’s endocannabinoid system (ECS), a complex network of receptors, enzymes, and endogenous cannabinoids (endocannabinoids). The ECS includes two main receptor types: CB1 (mostly in the brain and central nervous system) and CB2 (predominantly in the immune system and peripheral tissues). CBG binds to these receptors in = unique ways. Below is a breakdown of its specific interactions with CB1 and CB2 receptors, based on current research.
How CBG Interacts with CB1 Receptors CB1 receptors are present in brain function.
• Weak binding: CBG has a low binding affinity for CB1 receptors.
• Modulation of signaling: CBG can act as a modulator of endocannabinoid signaling by binding to the CB1 receptor.
• Biased agonism: Some studies suggest that CBG exhibits biased agonism on CB1 receptors. This means it activates certain signaling pathways more than others.
• Functional selectivity: CBG can distinguish between different conformations of the CB1 receptor.
• Indirect action: Some of CBG’s interactions with CB1 may be indirect, for example, by influencing the activity of other receptors or signaling molecules that, in turn, affect the CB1 receptor.
How CBG Interacts with CB2 Receptors CB2 receptors are found in high concentrations in immune cells, the gut, and bones.
• Partial agonist for CB2: CBG binds to and activates the CB2 receptor, though not as strongly as a full agonist.
• No psychoactive effect: Because CBG has a lower affinity for CB1 receptors compared to THC, its interaction with the CB2 receptor does not result in a “high.” Beyond receptors, CBG also interacts with other systems. It inhibits the reuptake of anandamide (an endocannabinoid).
Additionally, CBG acts on alpha-2 adrenergic receptors and 5-HT1A serotonin receptors. It also shows affinity for TRP channels. CBG is generally well-tolerated, with few side effects at moderate doses (e.g., 5-50mg daily), but consult a doctor, especially if on medications, as it may interact with certain drugs. Always source from reputable brands with third-party testing for purity.